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Pharmacokinetic Basis For Drug Treatment
1. Pharmacokinetics...1
2. Effects Of Gastrointestinal Disease On Drug Absorption...29
3. Effects Of Hepatic Disease On Clinical Pharmacokinetics...49
4. Drugs And The LIver: Clinical Applications...63
5. Pharmacokinetics And drug Excretion In Bile...77
6. Effects Of Cardiac Disease On Pharmacokinetics: Pathophysiologic Considerations...89
7. The Lungs And Metabolic Drug Clearance In Health And Disease...105
8. Effects Of Renal Disease: Pharmacokinetics CDonsiderations...119
9. Effects Of Renal Disease: Altered Pharmacokinetics...149
10. Implications Of Altered Plasma Protein Binding In Disease States...173
11. Pharmacokinetics Drug Interactions...195
12. Chronopharmacology An Further Steps Toward Chronotherapy...221
13. Effects Of Pregnancy On Pharmacokinetics...249
14. Clinical Pharmacokinetics: Pediatric Considerations...269
15. Pharmacokinetics Considerations In Geriatric Patients...283
16. Smoking Effects In Pharmacokinetics..311
17. Nonlinear Kinetics And Theophylline Ellimination...321
18. Drug Absorption And Disposition In Brun Patients...333
19. Computer-assisted Clinical Pharmacokinetics...349
20. Estimation Of Alterd Kinetics In Populations...357
21. Therapeutic Drug Monitoring...367
22. Establishing a Clinical Pharmacokinetics Laboratory...395
Appendixes...417
Appendix A: Theophylline Pharmacokinetics...419
Appendix B: Pharmacokinetics And Therapeutics...425
Appendix C: Information Pertinent In Monitoring Plasma Drug Concentrations...441
Appendix D: Additional Disease States Altering Drug Pharmacokinetics...447
Subject Index...453
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